ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: PLoS Med. 2019 Aug 6;16(8):e1002848. doi: 10.1371/journal.pmed.1002848.This systematic review identified 28 randomised trials (n =3976 women) of metformin vs. insulin for treatment for gestational diabetes. Metformin use was associated with lower birth weights (overall mean difference −107.7 g), lower ponderal indices, and lower odds of macros...

To read the full abstract: Diabetologia. 2020 Feb;63(2):324–337. PMID:31773193Maternal obesity is a risk factor for the development of type 2 diabetes in the offspring. Exposure to maternal obesity alters pancreatic islet structure and function, including reduced beta-cell mass and impaired glucose stimulated insulin secretion, which both increase susceptibility to type 2 diab...